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Student Number 953204046
Author Chun-li Peng(彭均莉)
Author's Email Address No Public.
Statistics This thesis had been viewed 1691 times. Download 455 times.
Department Chemical and Materials Engineering
Year 2007
Semester 2
Degree Master
Type of Document Master's Thesis
Language zh-TW.Big5 Chinese
Title Preparation of inorganic molecularly imprinted polymers based on Sulfamethazine by sol–gel process
Date of Defense 2008-06-04
Page Count 70
Keyword
  • Inorganic molecularly imprinted polymer
  • selectivity
  • sol-gel process
  • sulfamethazine
  • Abstract Inorganic molecularly imprinted polymer (IMIP) based on tetramethoxysilane (TMOS) and methyltrimethoxysilane (MTMOS) by sol-gel process has been developed. The conditions of preparation, the ratio of water to monomers (R), pH value of competition solution, calcination temperature, the ratio of TMOS to monomers (TMOS ratio), amount of hydrochloric acid and the reaction temperature were investigated. The competition experiment of the IMIP for template (sulfamethazine, SMZ) and analogue(sulfamethoxazole, SMO) were analyzed by High-Performance Liquid Chromatography (HPLC).
    The results showed that the higher selectivity of IMIP was obtained when pH value of competition solution was set to the pKa2 of SMZ. In addition, the adsorption of SMZ was increased with increase of the R value and the 2nd step calcination temperature. The crosslink and flexible of network were affected by TMOS ratio. Finally, amount of hydrochloric acid and the reaction temperature were also adjusted appropriately. The results showed that the best selectivity (α=21.8) of IMIP were obtained with R=10, the pH value of competition solution = 7.4, TMOS ratio = 1, amount of hydrochloric acid was 750 μl, the reaction temperature = 80℃ and the 2nd step calcination temperature =375°C. The IMIP (AdSMZ=2.18 μmol/g, α=21.8) was obtained the more efficiency than non-imprinted polymer (AdSMZ=1.62 μmol/g, α=6.23).
    Table of Content 中文摘要…………………………………………………………i
    英文摘要…………………………………………………………ii
    誌  謝…………………………………………………………iii
    目  錄…………………………………………………………iv
    圖 索 引…………………………………………………………vi
    表 索 引………………………………………………………… viii
    第 一 章前言…………………………………………………… 1
    1-1分子拓印高分子發展及應用…………………………1
    1-2分子拓印高分子技術與原理…………………………2
    1-3溶膠-凝膠程序………………………………………4
    1-3-1系統之pH值對溶膠-凝膠程序的影響………………4
    1-3-2含水量對溶膠-凝膠程序的影響……………………5
    1-3-3矽偶合劑添加對溶膠-凝膠程序的影響……………5
    1-4文獻回顧………………………………………………7
    1-5模板分子SMZ之介紹…………………………………8
    1-6研究目的……………………………………………… 9
    第 二 章實驗……………………………………………………10
    2-1實驗藥品……………………………………………… 10
    2-2實驗儀器……………………………………………… 12
    2-3無機分子拓印高分子之製備…………………………13
    2-4無機分子拓印高分子之物性測試……………………15
     2-4-1競爭吸附實驗…………………………………………15
     2-4-2氮氣吸附孔隙儀分析………………………………… 15
     2-4-3紅外線光譜分析………………………………………15
     2-4-4熱重分析儀分析………………………………………15
    第 三 章結果與討論……………………………………………16
    3-1R值對於無機分子拓印高分子的影響………………… 16
    3-2標準溶液pH值對於無機分子拓印高分子的影響……23
    3-3鍛燒溫度對無機分子拓印高分子的影響……………29
    3-4四甲氧基矽烷比例對無機分子拓印高分子的影響…36
    3-5HCl添加量對於製備無機分子拓印高分子之影響……43
    3-6系統反應溫度於製備無機分子拓印高分子響………50
    3-7比較有無添加模版分子SMZ之無機分子拓印高分子… 53
    第 四 章結論……………………………………………………55
    參考文獻………………………………………………57
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    Advisor
  • Hui Chen(陳暉)
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    Date of Submission 2008-06-20

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